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Setting the stage: The initial immune response to blood-stage parasites

Identifieur interne : 000054 ( an2020/Analysis ); précédent : 000053; suivant : 000055

Setting the stage: The initial immune response to blood-stage parasites

Auteurs : Allison N. Buc An ; Kim C. Williamson

Source :

RBID : PMC:6961725

Abstract

ABSTRACT

Individuals growing up in malaria endemic areas gradually develop protection against clinical malaria and passive transfer experiments in humans have demonstrated that this protection is mediated in part by protective antibodies. However, neither the target antigens, specific effector mechanisms, nor the role of continual parasite exposure have been elucidated, which complicates vaccine development. Progress has been made in defining the innate signaling pathways activated by parasite components, including DNA, RNA, hemozoin, and phospholipids, which initiate the immune response and will be the focus of this review. The challenge that remains within the field is to understand the role of these early responses in the development of protective adaptive responses that clear iRBC and block merozoite invasion so that optimal vaccines and therapeutics may be produced.


Url:
DOI: 10.1080/21505594.2019.1708053
PubMed: 31900030
PubMed Central: 6961725


Affiliations:


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PMC:6961725

Le document en format XML

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